Wondering which one is right for you: Weight loss injections Tirzepatide vs Semaglutide? Well, here lies the answer.
In the past few years, the weight loss industry has experienced a sudden increase in popularity for medications like Tirzepatide and Semaglutide. These names might sound unfamiliar to you, but their brand names, Mounjaro, Ozempic, Zepbound and Wegovy- have become your everyday household staples.
Tirzepatide, generally known as Mourjaro, is a FDA-approved medication for type 2 diabetes and weight loss. Semaglutide, the active ingredient in Ozempic and Wegovy, is also used for both purposes. According to Dr. Dina Peralta-Reich, Director of New York Wellness Medicine, these medications are similar but have distinct differences.
Tirzepatide targets two receptors, enhancing its weight loss potential, whereas Semaglutide weight loss targets just one. Studies show varying results, making it essential to consult a healthcare provider to determine which options suit you best.
Here in this blog post, we are going to explore their differences, efficacy and potential side effects to make an informed decision on your weight loss management.
What is Tirzepatide and How It Works?
Tirzepatide, found in Mounjaro and Zepbound, a powerful medication for adults suffering from type 2 diabetes and weight loss challenges. By targeting GIP and GLP-1 receptors, weight loss injections Tirzepatide curbs hunger and slows digestion, promoting a long-lasting feeling of fullness.
It also aids in lowering blood sugar levels by reducing liver sugar production and boosting insulin release. FDA-approved Zepbound for those with obesity and weight-related health issues and it is recommended to use alongside a healthy diet and exercise. Mounjaro specifically targets blood sugar control in type 2 diabetes patients to enhance their overall healthy well-being.
To learn more, how Tirzepatide weight loss near me works effectively, you can check our previous blog on Tirzepatide for Weight Loss Management: How Does It Work?.
What is Semaglutide and How It Works?
Semaglutide, the active ingredient in Ozempic, Wegovy and Rybelsus, is a GLP-1 agonist that effectively manages blood sugar and aids in weight loss management. By mimicking the GLP-1 protein, Semaglutide increases insulin production, helping transport glucose into cells for energy.
It also slows digestion and activates brain pathways that control hunger, making you feel fuller for longer. Ozempic reduces cardiovascular risks in diabetes, while Wegovy is approved for weight loss in obese individuals and overweight adults.
Check out our previous blog on How Non-Diabetics Can Access Semaglutide for Weight Loss Management? for more informaion.
Is Tirzepatide Better Compared to Semaglutide?
Studies show that compared to Semaglutide, weight loss injections Tirzepatide, might lead to greater weight loss. Nonetheless, more direct comparisons are necessary to reach the definitive conclusion. It is also crucial to consider individual variations in response to those medications- Semaglutide might be more effective for some individuals.
In a 72-weeks study, participants taking the highest dose of Tirzepatide lost an average of 21% their body weight, compared to a 3% loss in the placebo group.
Semaglutide has also shown positive results, with overweight or obese individuals losing an average of 5.9% of their body weight after 13 weeks and 10.9% after 26 weeks.
Tirzepatide’s potentially greater weight loss effect may be due to its dual action on both the GLP-1 and GIP receptors, whereas Semaglutide only targets the GLP-1 receptor.
For more information check Are Semaglutide Injections Safe for Weight Loss Management?.
Tirzepatide Vs. Semaglutide: Efficacy
Semaglutide and Tirzepatide weight loss management are two most promising medications and each demonstrating significant efficacy in clinical trials.
Semaglutide as seen in the STEP-1 trial, helped patients to lose an average of 12.4% more body weight compared to the placebo group. On the other hand, Tirzepatide with its dual mechanism, showed even greater potential in the SURMOUNT-1 trial, where patients on the maximum dosage lost an average of 17.8% more body weight than the placebo group. However, it is crucial to understand that not all patients experience these results. Sustained weight loss requires a combination of medication, dietary changes and regular exercise.
Dosages:
Weight loss injections Tirzepatide and Semaglutide are administered once in a week but have different dosing regimens. Semaglutide typically starts at 0.25mg per week, gradually increasing to a maintenance dose of 2.4mg per week.
On the other hand, Tirzepatide usually starts at 5mg per week, with the maintenance dose reaching 20mg per week.
Side Effects:
While weight loss injections Tirzepatide and Semaglutide can lead to significant results and are more effective than earlier medication, they also come with notable side effects.
In recent research, nearly 48.6% Semaglutide users reported side effects, the most common being Nausea (36.6%), followed by Diarrhea (8.6%), fatigue (6.3%), constipation (5.7%) and abdominal pain (5.1%).
Some patients (8.6%) experienced moderate symptoms that prevented dosage increases, while 2.9% had to stop the medication due to severe side effects.
Tirzepatide showed even higher side effect rates, with 81% of users in SURMOUNT-4 trial reporting issues, including Nausea (35.5%), Diarrhea (21.1%), constipation (20.7%) and vomiting (16.3%). Severe symptoms led 7% of patients to discontinue Tirzepatide. Additionally, both drugs pose risks of developing endocrine tumors, pancreatitis, and potential weight regain upon discontinuation.
The Bottom Line
Choosing between weight loss injection Tirzepatide and Semaglutide hinges on individual medical needs and preferences.
Tirzepatide, targeting dual receptors, shows potential for greater weight loss, while Semaglutide offers effectives results with its targeted GLP-1 action.
Both these medications need careful considerations of side effects which can impact treatment adherence. Consult with the licensed physicians of Precision Telemed to get a tailored weight loss management plan right for you. Remember, maintaining weight loss involves medication, diet modifications and regular exercise.
Visit us today and discover which option aligns best with your healthcare goals.
