Testosterone Replacement Therapy Injection for Men is primarily used to treat sexual dysfunction and symptoms of testosterone deficiency.

After a certain age, men experience symptoms like low sex drive, erectile dysfunction, mood swings, decreased energy and more. All these may be caused due to low testosterone levels.

While generally safe, testosterone injections can cause side effects which may vary. Read this article carefully to learn more on its uses, potential side effects, safety profile and more.

Understanding of Low Testosterone Levels

During puberty, the male sex hormone, Testosterone plays a crucial role in developing male physical traits. If a man has insufficient testosterone levels in his body, it is referred to as Hypogonadism or Low T.

Testosterone levels in men typically decline with age. Approximately 4 out of 10 men, aged over 45 experience low testosterone issues. Men with certain health issues like diabetes and obesity are also likely to have the Low T issue. 

Some of the common symptoms associated with LowT includes the following:


  • Decreased sperm count

  • Erectile dysfunction (ED)

  • Depression and anxiety

  • Changes in Libido

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  • Weight gain

  • Mood swings

Some men may also notice changes in the size of their testicles and penis, while some others may experience swelling issues in breast tissues. To treat this condition effectively, it is suggested to go for TRT therapy for men.

What is Testosterone Replacement Therapy Injection for Men?

Testosterone injections are basically administering isolated testosterone in males. In the United States, Testosterone Replacement Therapy (TRT) is gaining immense popularity.

Testosterone injection is available in various forms, like:


  • Testosterone cypionate (Depo-Testosterone)

  • Testosterone enanthate (Xyosted and also available in its generic form)

  • Testosterone undecanoate (Aveed, a long acting formulation)

How to Administer Testosterone Replacement Therapy Injection?

TRT drugs  are administered via an intramuscular injection, typically every 2 to 4 weeks.

These injections must be performed by a healthcare professional to avoid serious side effects or even fatality from improper use. The duration of the treatment is dependent on the specific condition being addressed.

Regular blood tests are necessary while on this medication. In boys treated for delayed puberty, testosterone can impact bone growth. Therefore, bone development might be monitored with X-rays every six months during treatment.

Consult your healthcare team about the use of this medication in children. Although it can be prescribed for children as young as 12 for certain conditions, specific precautions are necessary.

What Are the Potential Health Risks of TRT Injections?

Testosterone injections can benefit many men with low testosterone levels, but they may not be suitable for everyone. So, before undergoing TRT for men, it is crucial to inform your doctor about any health conditions.

Testosterone injection shots can increase the risk of certain health issues. Contact your healthcare providers immediately if you experience any of the following side effects:


  • Skin rash, itching, hives, swelling of the face, lips, tongue, or throat

  • Pain, swelling, or warmth in the leg, shortness of breath, chest pain

  • Experience chest pain or tightness, pain in shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded

  • High blood pressure

  • Liver injury: right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing of the skin or eyes, unusual weakness or fatigue

  • Mood swings, irritability, or hostility

  • Prolonged or painful erection

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  • Sleep apnea

  • Stroke: sudden numbness or weakness in the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision

  • Swelling of the ankles, hands, or feet

How Long Does It Take TRT Injection to Work?

There are various methods for testosterone replacement therapy, including injections, pellets, and topical creams. But the time it takes to effect may vary on individuals. Some men notice improvements within a few weeks, while others may require more time to see changes. 

Testosterone injections for men tend to boost libido faster than other symptoms. An increase in sex drive is often noticeable within 3 to 4 weeks and stabilizes around 6 weeks.

Increase in energy and stamina typically start around 3 months after undergoing the treatment and you can notice a continuous improvement over several weeks. 

Changes in body composition, such as increased lean muscle mass, strength, and reduced fat, start to appear between 3 and 4 months, leveling off between 6 and 12 months. These changes can continue gradually with regular exercise and long-term TRT use.

If you experience mood swings or depression, improvements may be noticeable about 6 weeks after starting TRT injections. Consult your healthcare provider or physician if your depression persists or worsens.

The Bottom Line

Testosterone replacement therapy injection for men can be beneficial, but only if you genuinely have low testosterone levels. If you are considering these injections, consult your doctor first. If they find a low T issue after properly diagnosing your medical condition, they will suggest either this therapy is good for you or not.

Here at Precision Telemed, we provide personalized TRT plans and injection dosage best suited to you. After online medical consultation, they will guide you properly to treat your lowT issue.

So, why wait? Let’s regain your vitality with our customized TRT treatment.

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